Gene: [11^/F2] coagulation factor II (prothrombin; fibrinogenase); disprothrombinemia; hypoprothrombinemia (prothrombin);


GEN

The gene length is 21 kb. Exons: 14.

FUN

Thrombin (fibrinogenase) is a serine proteinase with limited specificity (by Arg-). It converts fibrinigen into fibrin."

FAG

On the fibrin gene cluster, see FAM:F1/04q28.

REF

GEN,SEQ,MOP "Degen SJF, Davie: Biochemistry, 26, 6165-6177, 1987
CLO,COD,SEQ,GEN "Degen SJF &: Biochemistry, 22, 2087-2097, 1983
MUT,PEP,SEQ,MEB,PAT "Henriksen RA, Mann: Biochemistry, 27, N26, 9160-9165, 1988
PRO,LOC "Royle NJ &: Somat Cell Mol Genet, 13, 285-292, 1987

SWI

 SWISSPROT: P00734

KEY

hem, clot

CLA

coding, basic

LOC

11 p11-q12

MIM

 MIM: 176930

EZN

 ENZYME: 3.4.21.5

Смотрите также:

  • Gene: [20p112/THBD] thrombomodulin (endothelial cell trombin receptor); [THRM TM ]
  • Gene: [03^/PROS1] protein S, alpha (activated protein-C cofactor; vitamin K-dependent); thromboembolic disease, recurrent venous; [PROS ]
  • Gene: [13q34/F10] coagulation factor X (thrombokinase, prothrombinase); Stuart-Prower disease (coagulation factor X deficiency);
  • Коагуляционный фактор II (протромбин). Строение гена
  • Коагуляционный фактор F II (Протромбин). Биохимия
  • Коагуляционный фактор 2. Локализация гена